Benchmark indices were trading lower, with the heavyweights like Reliance Industries and ICICI Bank contributing to the fall.
The fall was largely on the back of weak cues from Asian peers, as investors resorted to profit booking after a strong rally last week.
Shares in Torrent Pharma rallied as much as 3.5 percent to Rs 1,365, while Unichem Labs gained 1.5 percent after the former acquired the domestic branded formulations business of Unichem Laboratories Ltd. for Rs 3,600 crores.
Jewellery maker, Titan gained as much as 22 per cent, after the company reported a strong set of earnings.
Meanwhile, most Asian markets were down with major losers being the Japanese Nikkei and the Korean Kospi.